Elevated plasma aldosterone is an independent risk factor for erectile dysfunction (ED), according to a new study. Fei Wu, MD, of Fudan University in Shanghai, China, and colleagues recruited 287 men aged 18–84 years, of whom 217 suffered from ED as diagnosed using the International Index of Erectile Function 5 (IIEF-5). The researchers divided subjects into 1 control group without ED and 3 ED groups based in IIEF-5 scores: mild ED, moderate ED, and severe ED. Mean plasma aldosterone levels were significantly higher in the ED group than in the control groups (365.6 vs. 328.0 pg/mL), the researchers reported online ahead of print in the World Journal of Urology. Mean aldosterone levels increased with ED severity, rising from 335.9 pg/mL in men with mild ED to 372.8 and 422.6 pg/mL in men with moderate and severe ED, respectively. “Thus, it is hypothesized that aldosterone may have a linear correlation with the IIEF-5 score in ED patients,” the authors wrote. Stepwise logistic regression analysis showed that elevated plasma aldosterone independently increases ED risk.
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Erectile dysfunction (ED) is a marker for undiagnosed diabetes, a new study finds. The presence of ED should prompt clinicians to screen for diabetes in men--especially middle-aged men--many of whom neglect to visit doctors' offices for preventative care. For the study, investigators led by Sean C. Skeldon, MD, of the University of Toronto in Canada, analyzed data from 4,519 men who responded to U.S. National Health and Nutrition Examination Surveys. The men answered a single question on ED: “How would you describe your ability to get and keep an erection?” To reduce confounding, prostate cancer patients were excluded. Given the association of ED with future cardiovascular disease (CVD), the researchers sought to identify the presence of CVD risk factors, including undiagnosed diabetes, hypertension, and hypercholesterolemia in men with ED. Earlier identification and treatment of these conditions might prevent CVD and untimely death. According to results published in the Annals of Family Medicine, men with ED had more than twice the odds of undiagnosed diabetes. The association was strongest for men aged 40–59 years: 1 in 10 with ED had undiagnosed diabetes compared with 1 in 50 without ED. The findings “support previous studies suggesting that the prognostic value of erectile dysfunction for CVD is strongest in middle-aged men younger than 60,” according to the researchers. They found no associations of ED with undiagnosed hypertension or hypercholesterolemia. In addition to diligently screening for diabetes, clinicians should also obtain sexual histories, the investigators suggested. |
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