Patients who have medical risk factors for chronic kidney disease (CKD) are at increased risk of progressive renal impairment despite the use of partial nephrectomy (PN), according to new study findings published online in BJU International. The study, by Prassannah Satasivam, MD, of Monash Health in Melbourne, and colleagues, included 488 patients undergoing surgery for renal cell carcinoma (RCC). Of these, 156 underwent PN and 332 underwent radical nephrectomy (RN). RN was associated with a 2.7 times increased risk of a new-onset CKD (estimated glomerular filtration rate [eGFR] below 60 mL/min/1.73 m2) compared with PN. Patients undergoing PN, however, were still at risk of new-onset CKD. The proportion of PN patients who experienced new-onset CKD more than 6 months after surgery was 7% for those without CKD risk factors, including hypertension, diabetes mellitus, cardiovascular disease, obesity, high cholesterol, family history of CKD, and age, the researchers reported. This proportion rose to 24%, 30%, and 42% for patients older than 60 years and those with hypertension or diabetes mellitus, respectively. “We contend that, where appropriate, PN should be considered in those patients with normal preoperative renal function and who possess risk factors for future impairment,” the authors concluded.
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Higher intake of lycopene is associated with a lower risk of renal cell carcinoma (RCC)among postmenopausal women, researchers reported in Cancer (2015;121:580-588). Researchers led by Cathryn H. Bock, PhD, MPH, of the Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, analyzed data from 96,196 postmenopausal women who enrolled in the Women's Health Initiative study from 1993 to 1998 and were followed through July 2013. The investigators analyzed the risks for RCC associated with intake of lycopene, α-carotene, β-carotene, β-cryptoxanthin, lutein plus zeaxanthin, vitamin C, and vitamin E, all micronutrients that have antioxidant properties. During follow-up, 240 women were diagnosed with RCC. Compared with women in the lowest quartile of lycopene intake, those in the highest quartile had a significant 39% lower risk of RCC. The researchers found no significant association between RCC risk and other micronutrients analyzed in the study. |
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